This study was designed to understand how AAS abuse effects the brain

This study was designed to understand how AAS abuse effects the brain

In this 2019 study that was designed to understand how AAS abuse effects the brain, when researchers compared 4 different steroids side by side

Testosterone, Nandrolone, Stanozolol, and Trenbolone

and cellular toxicity was determined by measuring mitochondrial activity, lactate dehydrogenase (LDH) release, and caspase-3/7 activity.

What did we see ?

Overall, we found that supra-physiological concentrations of AASs induce cell death in mixed primary cortical cultures, but to different extents, and possibly through various mechanisms.

With respect to the parameters assessed in this study Nandrolone appeared to be the most toxic AAS for the Brain

 

 
Nandrolone, unlike the other AAS studied, indicated an effect on mitochondrial activity after 24 h.
 
Furthermore, single-dose exposure with Testosterone, Nandrolone and Trenbolone increased LDH release, while no effect was detected with Stanozolol.
 
However, all of the four steroids negatively affected mitochondrial function and resulted in LDH release after repeated exposure.
 
Testosterone, Nandrolone, and Trenbolone caused their toxic effects by induction of apoptosis, unlike Stanozolol that seemed to induce necrosis.
 
Overall, we found that supra-physiological concentrations of AASs induce cell death in mixed primary cortical cultures, but to different extents, and possibly through various mechanisms.
 
With respect to the parameters assessed, Nandrolone appeared to be the most toxic AAS, while Testosterone, Stanozolol, and Trenbolone disposed similar effects but to a lesser extent.

 I have long maintained Nandrolone might be good for your Hair.. but it might turn out to be one of the worst Steroids for your Brain.. if you have been following me for a long time you will know of my debates with the Nandrolone and Dbol crowd two of the worst Steroids for your Brain stacked ontop of each other, sounds great.. huh

If you have been following me for a long time you will know of my debates with the Nandrolone only and Nandrolone and Dbol crowd

Two of the worst Steroids for your Brain stacked ontop of each other, sounds great.. huh.. little wonder most of them are just a little off balance – think Mike Mentzer, Robbie Robinson, Lee Priest, the entire Camel Crew haha

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Victor Black