Nandrolone Only the Hair Friendly Steroid. But is there really any Proof ?

Nandrolone Only the Hair Friendly Steroid. But is there really any Proof ?

Don’t do it Victor!

Ah fuck it.. haha

Nandrolone Only the Hair Friendly Steroid. But is there really any Proof?

The Nandrolone only Tribes last remaining foothold is ” Hair Friendly”

I will often concede that, in the hopes that giving a small win might not alienate me completely

But since that bridge is burned beyond repair, ever.

Understand this is NOT evidence, this is NOT proof

Its mere observation on an n = 1 basis

Nandrolone only comes from the days when BB had nice Hair so they say at least

But is that really True?

This is the Golden Poster Boy for the Nandrolone only Tribe Mr Mike Mentzer around late 40s and me the “evil” Victor Black

Is his Hair really any better, I mean at the age Men start to experience Hair Loss in their 40 – 50’s?

I think we can look at guys and say nice Hair but Mike Retired at 29..

How many guys have Hair Problems at 29?

Understand is the NOT evidence, this is NOT proof

Its mere observation on an n = 1 basis

AND even the observation part IMO is messed up and biased

He had nice Hair at 29? Oh Agreed Very Nice

But so did I.. the evil Victor Back.

What about in the late 40s ?

Let’s be honest here was he doing better than this Test and Masteron Advocate?

Dbol is potentially Neurotoxic – and its not alone..

Dbol is potentially Neurotoxic – and its not alone..

No sacred cows !

( A sacred Cow is an idea, custom, or institution held, especially unreasonably, to be above criticism )

If you are really serious about learning about PEDs, then there can be no sacred cows.. All PEDs are on the table for critical review..

Trenbolone is potentially Neurotoxic.

A few years ago a study was released that looked at the impact of Trenbolone on the Male Rat Brain, where we saw increased levels of β-amyloid Plague that resulted in a large number of guys placing Trenbolone in the ” potentially Neurotoxic” basket..

and possibly quite rightly so..

But I wonder how many that did that know that Methandienone ( Dbol ) also amplifies β-Amyloid Induced Toxicity ?

I have never heard anyone warning guys off using Dbol because it does what Trenbolone does to your brain.

Why ? Mostly because studies rarely compare multiple steroids side by side for the effects. Guys are presented with one study that shows X drug might do XYZ and then in their mind that drug, and only that drug, does that.

Comparing Testosterone, Nandrolone and DBol for Neurotoxicity

In this study Testosterone, Nandrolone and DBol were compared here side by side re amplified Ab-Induced toxicity.

In this test all drugs were tested for their ability to affect neuronal susceptibility to β-amyloid -induced toxicity in mixed cortical cultures at higher concentrations of 100 nM,

Methandrostenolone ( Dbol ) amplified Ab-induced toxicity.

Here Testosterone did not influence Ab toxicity, however Methandrostenolone ( Dbol ) amplified Ab-induced toxicity.

Overall this study provides evidence that two AASs with a different pharmacological profile, namely, Nandrolone and Methandrostenolone, can affect neuronal survival at suprapharmacologic doses, raising a serious concern for steroid abusers, who have micromolar concentrations of AASs in their brain (Lukas, 1996; Wu, 1997; Daly et al., 2001).

The relevant sites for the neurotoxic action of Nandrolone and Methandrostenolone appear to be membrane-associated ARs and membrane associated-GRs, respectively.
Its important to note here that these concentrations of the drugs were not directly neurotoxic however they where able to increase neuronal susceptibility to the apoptotic stimulus provided by Ab(25–35).

Laymans Takeaway ?

I have no problem with guys placing Trenbolone in the ” potentially Neurotoxic” basket.. as I say it probably deserves to be there..

However no sacred cows !

What else is in that basket ?

DBol and Nandrolone for a start !

Human exposure to AASs including Dbol and Nandrolone and Trenbolone may result in a compromised brain, more susceptible, later in life, to the onset or progression of diseases not usually linked to drug abuse, especially neurodegenerative diseases (e.g .,Alzheimer’s disease).

Here is the real issue..

I suspect if we actually had the data on all commonly used Anabolic and Androgenic Steroids that Testosterone would be the only compound that did not slap us around here..

I imagine it would be a case of they do “too varying degrees” with outcomes both compound and dosage dependant

But sadly because Trenbolone is the one drug we have that specific data on, from ” that one specific study” it then becomes in guys minds the one drug you should not use.

This is the whole SARMs argument, there will be SARMs advocates reading this rubbing their hands together saying ” see I told you so”

” Lucky we use SARMs haha ”

When of course in reality what all this actually means is we have fragments of insight for what might be true for Trenbolone and Dbol and Nandrolone, really just a few scraps to think about, and not a fucking clue what SARMs are doing to your Brain.

Question from Master Class Member

What do the BSA conjugates tell us ?

I am not an organic chemist so, to the best of my understanding here

The BSA conjugates are used here for they are are cell impermeable and so preferentially target membrane Androgen receptors

Given the higher responses seen from the BSA conjugates its suggesting cell membrane AR are the relevant site for the Neurotoxic Effect of Steroids

Victor Black

Nandrolone, Women and Cardiovascular Dysfunction

Nandrolone, Women, Cardiovascular Dysfunction. 

Life would be so much easier if we did not have to try to interpret ” indirect data” when it comes to AAS Harm Reduction Practices but that honestly is just wishful thinking…

This is simply our reality…

In this 2017 surrogate study they looked at the consequence on Cardiovascular Function when female Rats were administered Nandrolone ( ND )

The study showed new insights into the Cardiotoxic effects of ND.

The study showed that the chronic use of ND treatment induces endothelial dysfunction, which alters vascular responsiveness by a mechanism that involves NO pathway and possibly increased oxidative stress.

These findings add to the discussion that ND treatment might increase the risk for vascular injury in Women gender, a response that could predispose them to elevated risk of cardiovascular diseases

Now here IMO is the most important part of the study.

The study included the comparing the vascular reactivity profiles between female rats submitted to estrogen-deficiency animal models and Nandrolone exposure models

High doses of Nandrolone Decanoate induce vascular dysfunction in females very similar to the alterations observed in an estrogen deficiency model

” While we cannot discern whether the negative vascular effects observed in ND-treated females are due to a direct effect of ND or to an indirect effect of serum levels of testosterone and estrogen, the data does suggest that the reduction of circulating levels of estradiol in ND treated-females could lead to an impairment of vascular reactivity. “

My Takeway ?

Women have a better Cardiovascular Health Risk Profile than Men, and its Estrogen that provides that added Protection.

Submit female Rats to “Estrogen Deficiency” and they loose that Protection..

Submit female Rats to ” Nandrolone exposure” and they loose that Protection..

Estrogen is Cardiac Protective… in female Rats

In Women and in Men..

Nandrolone when used by itself – negates that Protection..

Long-term treatment with Nandrolone Decanoate impairs mesenteric vascular relaxation in both sedentary and exercised female rats


•  Nandrolone Decanoate (ND) impaired mesenteric vascular reactivity in female rats.
•  ND-induced vascular alterations were likely mediated by a reduction of NO pathway.
•  Exercise training did not improve the vascular alterations induced by ND treatment.
• ND led to vascular dysfunction similar to those found in ovariectomized female rats.Nandrolone Decanoate (ND) is an Anabolic Androgenic Steroid (AAS) that under abusive regimen can lead to multiple physiological adverse effects. Studies of AAS-mediated cardiovascular (CV) alterations were mostly taken from male subjects, even though women are also susceptible to the effects of AAS and gender-specific differences in susceptibility to vascular diseases exist. Here we investigate ND-induced vascular reactivity alterations in both sedentary and exercised female rats and whether these alterations depend on endothelium-derived factors. We show that chronic exposure of female Wistar rats to ND (20 mg/Kg/week for 4 weeks) impaired the vascular mesenteric bed (MVB) reactivity to vasodilator (acetylcholine) agonist. The endothelium-dependent Nitric Oxide (NO) component was reduced in ND-treated rats, whereas neither the endothelium-derived hyperpolarizing factor (EDHF) component nor prostanoids were altered in the MVBs. Endothelial dysfunction observed in ND-treated rats was associated with decreased eNOS (Ser1177) and Akt (Ser473) phosphorylation sites and upregulation of iNOS and NADPH oxidase expression. Exercise training by weight lifting in water did not improve the vascular alterations induced by ND treatment. ND treatment also significantly reduced the serum levels of estradiol in females, overriding its CV protective effect. These results help uncover the role of ND modulating endothelial function in the setting of CV disease caused by the abuse of AAS in females. If this translates to humans, young women abusing AAS can potentially lose the cardio protective effect rendered by estrogen and be more susceptible to CV alterations

Nandrolone is an Aldosterone Agonist

Nandrolone is an Aldosterone Agonist

If you have ever made the mistake of allowing yourself to be drawn into a discussion with a “Nandrolone only” zealot you will know that they love to wheel out all manner of Bro Science justifications for not using Testosterone as a Base in PED cycles

Often they will claim because of the lower rate of conversion to Estrogen you will hold less water than when using Testosterone.

Don’t get me wrong, I think Nandrolone is a fabulous compound and it is justified in anyone consideration as an offseason compound.

However use it at Supraphyisologiocal dosages and your Aldosterone levels go up just like with Testosterone 

Na+ and K+ concentration also rose from the initial period of administration to the terminal phase of study, no surprises there



IGF-I with Nandrolone or Stanozolol elevates E2

Now this is interesting

Looks like Aromatase expression is induced by the combined treatment of IGF-I with nandrolone or stanozolol to levels higher than those obtained with the single agents

Takeaway if you use rHGH /IGF-1 Lr3 and AAS in combination

Expect higher Estrogen Control Issues, much much higher with Nandrolone

Victor Black