Understanding Intra-individual “Genetic Response”

Understanding Intra-individual “Genetic Response”

Understanding Intra-individual “Genetic Response”

If you look at any study that is designed to review ” dosage response ” .. across the full spectrum of studies from Training Studies on Naturals to dosage response on PEDs you will always see a degree of individual response to the same inputs, always..

Let’s go so far to say you will never ever see a large group of randomly chosen individuals that all respond exactly the same.. period.

This is universally true.

Below I offer 3 studies

Figure 1 is a study on Natural Trainers showing the degree of variation from exactly the same training stimulus under controlled conditions.

Note the degree of variation here from “non-responsder” to ” wow, holly **** wow”, who the hell was that guy ? haha

Importantly you should not ” compare” yourself to either end of the bell curve.. its enough here to understand those guys do exist.

Fiqure 2 shows the IGF-1 response to exactly the same dosage of rHGH under clinical conditions.. This is an eye-watering 0.3IU/kg of rHGH a day.. ( 30 IU a day for me ) the red bars show how far the range of response to the dosage was over the individuals tested.

Fiqure 3 shows the increase in Muscle Cross-Sectional Area for Men given graded dosages of Testosterone.. ie ” Growth”

Here you you can see here one man given just 125mg a week of Testosterone saw more ” Cross Section Area Growth” than the average of the guys on 300mg a week

Hell he even saw equal or more growth than 3 of the guys on 600mg a week ! 4 .8 times as much as he got !

If you are unable to look at these studies and acknowledge the simple fact that over a group of individuals there are always going to be outliers both in terms of a positive response to a training input and a pharmacological one I am not sure you can ever be “ reasoned” with from an evidence base.

The idea of a “ wide range of responses” from individuals is simply universally understood in applied science.

Its not a coincidence that most high-level professionals in any sport are the “outliers” to genetic response to training stimulus .. haha

and I am sorry but if you are struggling with the idea that a ” few” guys just got the best cards.. that they respond in ways that mere mortals dont to exactly the same inputs, all I can really suggest here is you spend some time understanding the idea of ” interindividual genetic response to stimulus” .. this is not “opinion”

Indeed its the very reason we don’t run studies on one man.. for n = 1 does not mean anything… literally due to this very reason, we need to see the ” average” over a group of individuals just in case we chanced upon the non-responder or the hyper responder in our selection of ” one man” for the study..

This is ultimately a game of genetics.. and yes most ” sports” are..

If you are like me.. ” Mr Average” for I am neither blessed nor cursed.. ” hard work” buys you a ticket to the game, 100 percent that is ” why” I am here… I know what I am doing and I work hard..

And a hard-working Man with average Genetics will always be able to beat a lazy Man with great genetics, but once the gifted individual steps up and like in these studies he does what I do, follows me ” step for step”… I get left behind..

All you can really do is focus on your own game.. and accept.. this is ultimately a game of genetics..

Be the best version of you..

Victor Black

Genetics – Androgen Receptor (AR) CAG repeat Polymorphism in Andrology

Genetics – Androgen Receptor (AR) CAG repeat Polymorphism in Andrology

Genetics – Androgen Receptor (AR) CAG repeat Polymorphism in Andrology

In the last decade, ample evidence has demonstrated the growing importance of androgen receptor (AR) CAG repeat polymorphism in andrology. This genetic parameter is able to condition the peripheral effects of testosterone and therefore to influence male sexual function and fertility, cardiovascular risk, body composition, bone metabolism, the risk of prostate and testicular cancer, the psychiatric status, and the onset of neurodegenerative disorders.

In this review, we extensively discuss the literature data and identify a role for AR CAG repeat polymorphism in conditioning the systemic testosterone effects. In particular, our main purpose was to provide an updated text able to shed light on the many and often contradictory findings reporting an influence of CAG repeat polymorphism on the targets of testosterone action

Influence of CAG Repeat Polymorphism on the Targets of