Injectable vs Oral admin of SR9009

Injectable vs Oral admin of SR9009

Be very careful where you get your information from

I have said this many time before but be careful where you get your information from.

There is nothing new about companies that “sell supplements” based on taking study data and twisting it up and turn it around and try to use it to sell you something that does not work that way..

Think 99{4810c8228756a9189e64fcffe2b64504834fd1a9aa1761a0e9a85eac56097be8} of supplements in your local GNC

Its the oldest game in town.. and it’s also true in the world of SARMs

Let’s look at the Compound SR-9009

There are some great studies that show really amazing outcomes in surrogates for this compound.. for a number of outcomes .. very impressive and interesting data.

But all these studies are based on injectable versions of SR9009

Why ? Oral Bio-availability. 

In 2013 a study was published that showed in a pharmacokinetic study of the compound SR 9009 very little is absorbed orally 2.2{4810c8228756a9189e64fcffe2b64504834fd1a9aa1761a0e9a85eac56097be8} ( again surrogate data )

2.2 {4810c8228756a9189e64fcffe2b64504834fd1a9aa1761a0e9a85eac56097be8} ? What ?

Overall, they tested with mice 3 agonists of REV-ERBα, number 3 being SR 9009, plus a bunch of their derivates (for a total of 23 compounds).

With the absorption rate for Oral Admin being 2.2{4810c8228756a9189e64fcffe2b64504834fd1a9aa1761a0e9a85eac56097be8} versus 100{4810c8228756a9189e64fcffe2b64504834fd1a9aa1761a0e9a85eac56097be8} by intravenous injection

Even the lead developer of the compound is on record saying

” Prof. Burris said of SR9009’s use in humans: “I just recently found out that someone is selling SR9009 in a manner that is “supported” for human use in bodybuilding. I agree with your comments. The drug does in fact alter the circadian rhythm (in mice) and we would need to assume in humans – and we don’t know if it is beneficial or detrimental at this point. SR9009 was designed as a “tool” molecule to determine if we should pursue making more drug like compounds that could be used to treat disease. Of course, the data is supportive of going forward – and we are designing better compounds – but the issue is that SR9009 has several issues that make it unsuitable for human use. Firstly, it has no oral bioavailability. I know the company selling this is indicating taking it orally is ok – but it doesn’t even get into the blood. ”

Of course, this does not stop people trying to sell you Oral Versions of the compound.. after all lets not let the facts get in the way of making money.

Be very careful where you get your information from

There is nothing new about companies that “sell supplements” based on taking study data and twisting it up and turn it around and try to use it to sell you something that does not work that way..

You will save more than the Membership Price of Master Class in ” wasted” money.. let alone ” better outcomes”

Takeaway ?

Injectable SR9009 ? Interesting
Oral SR9009 ? Total waste of your money

Victor Black