Another Study raising the issue of Neurotoxicity from the Chronic Use of Dbol – Methandrostenolone

Another Study raising the issue of Neurotoxicity from the Chronic Use of Dbol – Methandrostenolone ( in a Rodent Model )


Neurotoxicity is one of the areas of AAS Harm Reduction that I simply need to better understand, I have no problem raising my hand here and saying it stretches my poor layman skill set right out the gate. haha

This is a Rodent Study that I really don’t have much to say about here beyond this

In this study we are looking at the impact of the Adolescent Brain.

Does this apply to the mature brain ?

In this study we are looking at Dbol ( Methandrostenolone )

Does this only apply to Dbol or all AAS ?

I have previously discussed the idea that Neurotoxicity might be related to the mechanism or action of individual PEDs

Read more on that here.. 

It has been proposed that activation of ARs may elicit opposite effects on cell survival (i.e., detrimental or beneficial) depending on whether membrane ARs or intracellular ARs are activated.

There are some studies that suggest Dbol is only a weak agonist of the ARs and that most of its anabolic activity likely comes from nonAR-mediated effects (Fragkaki et al., 2009)

and the elevated neurotoxicity of the drug Dbol when compared to Testosterone was fully prevented by the glucocorticoid receptor (GR) antagonist RU486, suggesting its its Dbol’s action on the glucocorticoid receptor (GR) that underlies this impact

Is that what we are seeing here as well ?

We know rHGH has some ability to offset the impact of Neurotoxicioty from Nandrolone use… does that apply here ?

So I have more questions that answers to offer here

I will try to better understand this.. and make a more insightful post when I do

Takeaway for now ?

Steroids have the potential to be Neurotoxic.. I think that is just fact

Different Steroids have the potential to be more or less Neurotoxic .. moderate Testosterone is Neuroprotective.. well both Testosterone and Estrogen are Neuroprotective.

IMO just raising this awareness of Neurotoxicity is a good start..

I think too many guys are worried about superficial side effects like Gyno and Hair Loss and Acne – we can fix that

Maybe you should worry more about White Matter Loss instead ?

What matter more to you, your Brain or your Hair ?

One guess who I will asking help from to understand this..Scott Howell.

He is a crazy busy Man so when he has some time, I will try to get his take.

VIctor Black

Dbol is potentially Neurotoxic – and its not alone..

Dbol is potentially Neurotoxic – and its not alone..

No sacred cows !

( A sacred Cow is an idea, custom, or institution held, especially unreasonably, to be above criticism )

If you are really serious about learning about PEDs, then there can be no sacred cows.. All PEDs are on the table for critical review..

Trenbolone is potentially Neurotoxic.

A few years ago a study was released that looked at the impact of Trenbolone on the Male Rat Brain, where we saw increased levels of β-amyloid Plague that resulted in a large number of guys placing Trenbolone in the ” potentially Neurotoxic” basket..

and possibly quite rightly so..

But I wonder how many that did that know that Methandienone ( Dbol ) also amplifies β-Amyloid Induced Toxicity ?

I have never heard anyone warning guys off using Dbol because it does what Trenbolone does to your brain.

Why ? Mostly because studies rarely compare multiple steroids side by side for the effects. Guys are presented with one study that shows X drug might do XYZ and then in their mind that drug, and only that drug, does that.

Comparing Testosterone, Nandrolone and DBol for Neurotoxicity

In this study Testosterone, Nandrolone and DBol were compared here side by side re amplified Ab-Induced toxicity.

In this test all drugs were tested for their ability to affect neuronal susceptibility to β-amyloid -induced toxicity in mixed cortical cultures at higher concentrations of 100 nM,

Methandrostenolone ( Dbol ) amplified Ab-induced toxicity.

Here Testosterone did not influence Ab toxicity, however Methandrostenolone ( Dbol ) amplified Ab-induced toxicity.

Overall this study provides evidence that two AASs with a different pharmacological profile, namely, Nandrolone and Methandrostenolone, can affect neuronal survival at suprapharmacologic doses, raising a serious concern for steroid abusers, who have micromolar concentrations of AASs in their brain (Lukas, 1996; Wu, 1997; Daly et al., 2001).

The relevant sites for the neurotoxic action of Nandrolone and Methandrostenolone appear to be membrane-associated ARs and membrane associated-GRs, respectively.
Its important to note here that these concentrations of the drugs were not directly neurotoxic however they where able to increase neuronal susceptibility to the apoptotic stimulus provided by Ab(25–35).

Laymans Takeaway ?

I have no problem with guys placing Trenbolone in the ” potentially Neurotoxic” basket.. as I say it probably deserves to be there..

However no sacred cows !

What else is in that basket ?

DBol and Nandrolone for a start !

Human exposure to AASs including Dbol and Nandrolone and Trenbolone may result in a compromised brain, more susceptible, later in life, to the onset or progression of diseases not usually linked to drug abuse, especially neurodegenerative diseases (e.g .,Alzheimer’s disease).

Here is the real issue..

I suspect if we actually had the data on all commonly used Anabolic and Androgenic Steroids that Testosterone would be the only compound that did not slap us around here..

I imagine it would be a case of they do “too varying degrees” with outcomes both compound and dosage dependant

But sadly because Trenbolone is the one drug we have that specific data on, from ” that one specific study” it then becomes in guys minds the one drug you should not use.

This is the whole SARMs argument, there will be SARMs advocates reading this rubbing their hands together saying ” see I told you so”

” Lucky we use SARMs haha ”

When of course in reality what all this actually means is we have fragments of insight for what might be true for Trenbolone and Dbol and Nandrolone, really just a few scraps to think about, and not a fucking clue what SARMs are doing to your Brain.

Question from Master Class Member

What do the BSA conjugates tell us ?

I am not an organic chemist so, to the best of my understanding here

The BSA conjugates are used here for they are are cell impermeable and so preferentially target membrane Androgen receptors

Given the higher responses seen from the BSA conjugates its suggesting cell membrane AR are the relevant site for the Neurotoxic Effect of Steroids

Victor Black