The application of Anabolic Steroids in the Treatment on Inflammatory Bowel Disease
The application of Anabolic Steroids in the Treatment on Imflamatory Bowel Disease
Testosterone Derivatives, Nandrolone, Stanazol, Danazol, Anavar and Proviron
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Crohn’s Disease (CD) and Ulcerative Colitis (UC), the constituents of Inflammatory Bowel Disease (IBD), are the most destructive benign diseases of young adults. Two-hundred thousand young men and women in North America will have major bowel resection annually, half to experience a premature death and many an increased risk of colorectal cancer.
New cases in the youngest quadrille are appearing at a 0.5 percent rate per year.
Adalimumab, the last pharmaceutical TNF-inhibitor drug approved for IBD was 17 years ago. Adalimumab’s failure rate is 40 percent by year two, 60 percent by year five, and the 12-year German study questions whether there is any long-term gain in quality of life at all. The problems to date in understanding and treating IBD are that no one has identified the cause, no specific biomarkers are recognized, no alternatives to overtly toxic medications and no alternatives exist for inevitable surgical resections.
However there are now serum hormonal biomarkers that are highly predictive of flairs in Crohn’s diseases; the first being the nuclear membrane Estrogen Receptor-beta/Estrogen Receptor-alpha ratio.
The second being bioavailable testosterone measured as the Free Androgen Index. Causation is clearly demarcated to hormonal dysregulation at the Hypothalamic-Pituitary-Gonadal Axis suppressing testosterone production.
Five inexpensive, generic, FDA approved anabolic steroid medications have been successfully used to treat IBD, albeit, not the recognized standard of care.
After initial medical information intake, measure Gender Specific Medicine biomarkers of gonadal hormones (causation) and then treat to normalize these biomarkers.
Admixtures of anabolic steroids should reset the biomarkers and reduce the autoimmune, inflammatory, and systemic aspects of disease.
Remission may be attainable with even the most resistant Crohn’s and Ulcerative Colitis patients as observed in the Case Reports.
Study 1 – Testosterone therapy in men with Crohn’s disease improves the clinical course of the disease: data from long-term observational registry studyTestosterone therapy in men with Crohn’s disease 2015
Study 2 – Five Anabolic Steroids in the Treatment of Inflammatory Bowel Disease – 2019Inflammatory Bowel Disease
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