Trenbolone the Chemical Uncoupler

Trenbolone the Chemical Uncoupler ? think DNP, BAM 15

For decades we have known that moderately high to high dosages of Trenbolone results in both significant fat loss contribution, very disproportionate in comparison to the contribution we see from other Androgens including Testosterone and makes you sweat like pig at night, stories of waking up with soaked bedsheets are not uncommon.

It is my belief this is one of the observational reasons that so many think that Trenbolone is ” so much more powerful in its Androgenic Potential ” than Testosterone or other Testosterone Derivatives

Because they think that its Trenbolones Androgenic Potential that causes these outcomes

I am going to challenge that and explain how its Trenbolones action on the Progesterone Receptor that is causing this outcome..

Here is my Hypothesis.

Trenbolone is both a capable Androgen and a capable Progestin in that its is able to act powerfully on the Progesterone Receptor.

So ?

The role of Brown adipose tissue (BAT) in Adults is still controversial. 

The heat generating properties of BAT a major component of adaptive thermogenesis in the newborn mammal during the immediate acclimatisation to the relatively cold extra-uterine environment, but the presence of active BAT in adults raises the possibility of a therapeutic target for weight loss interventions.

The importance of white adipose tissue (WAT) is well documented and its role in health and disease has been long established. In contrast, the importance of Brown adipose tissue (BAT) in adults has only been identified much more recently.

The BATspecific uncoupling protein (UCP)1 enables BAT to convert chemical energy in fatty acids and other substrates to heat.

Mitochondrial uncoupling protein 1 (UCP1) is responsible for nonshivering thermogenesis in brown adipose tissue (BAT). UCP1 uniquely uncouples the mitochondrial energy cascade from adenosine triphosphate (ATP) production, instead releasing the energy as heat.

This is reflected in the basal oxygen consumption rate of human BAT, which has been shown to be approximately 350 pmol/min compared to subcutaneous WAT, which is almost 100 times less

BAT is innervated by the sympathetic nervous system (SNS) through noradrenaline (NA) acting on the β-adrenoreceptor (AR), which then promotes lipolysis and the resulting increase in intracellular free fatty acids activates UCP1.

The β3-AR subtype is the primary AR responsible for the NA-induced upregulation of BAT through increased UCP1 expression and activity, and raised cyclic adenosine monophosphate (cAMP).

β3-AR are only present in the mature adipocyte, whereas β1 and β2-ARs are found in preadipocytes.

Brown-like cells have been shown to be present in deposits of WAT and are termed beige or BRITE (BRown-In-whiTE) adipocytes.

Getting to the point here I promise..

The effects of Progesterone on BAT

Brown Adipocytes express receptors for Progesterone, Estrogen and Testosterone

At lower concentrations, Progesterone but not E2 increases UCP1 NA-induced mRNA expression in BAT cells. Both E2 and progesterone increase the size and number of lipid
droplets in BAT cells compared to testosterone, suggesting an increased metabolic – and presumably thermogenic – capacity of the cell

Progesterone has a positive effect on factors associated with mitochondrogenesis and BAT differentiation (i.e., PPARγ and GABPA-TFAM axis)

The effect of Testosterone on BAT

The primary male sex steroid testosterone appears to have opposite effects to Estrogen and Progesterone, at least in vitro, resulting in a decrease in thermogenic capacity.

Testosterone promotes increased gene expression of the anti-lipolytic receptor α2-AR and reduces both NA-induced expression of UCP1 , and PGC1α in conjunction with a decline in the number and size of lipid droplets  and lipolytic sensitivity.

However in vivo, testosterone administration consistently results in decreased body mass in rodent models and, where measured, resting metabolic rate is increased.

It appears that testosterone may exert its effect on weight loss through a combination of decreased energy intake and increased resting metabolic rate with or without a change in BAT activity. The exact balance of mechanisms involved may therefore vary depending on species, age and duration.

As well as increasing the resting metabolic rate, it seems likely that testosterone promotes exercise. The recent but still controversial discovery of the hormone irisin, which is released from muscle during exercise and promotes BAT function, may suggest a mechanism by which testosterone can have an indirect stimulatory effect on brown adipocytes in vivo, overcoming the inhibition seen in vitro.

Takeaway ?

IMO its Trenbolone’s interplay with the Progesterone Receptor in Brown adipose tissue (BAT) that is responsible for both its role in significant fat loss contribution, and makes you sweat like pig at night.

Important Consideration here..

A great many guys that use Trenbolone when they are dieting also use Clenbuterol, also an agonist at the beta-2 and beta-3 adrenergic receptor = doubling up the stimulus  here.

If you really want to get your ” sweat on” ? .. Trenbolone + Clenbuterol + DNP …

Finally the risk here ?

Steroidal Progestins are NOT good for our Brains.. if you are sweating excessively and that is Trenbolones interplay with the Progesterone Receptor that is a decent proxy for ” too much”

NO I have no direct evidence to support this.. its a case of follow the thread or dont.. up to you.