When you come to understand that all these Acne Clinical Treatment Models ” work” via the same pathway…
Then it makes a lot more sense to
1, try to understand what that pathway is..
So what is P53 expression ?
Do you know ? If you dont that is where we start..
2, ask ourselves what are the treatment options that are going to best serve us, with the least number of side effects detrimental to our goals
Where Evidence and Experience meet.
Victor Black
Side Effects from Accutane for Acne Treatment
Earlier today I posted briefly about an upcoming series of posts I will make relevant to managing AAS Use induced Acne.
I had intended to hold off on this end of the discussion – re the use of Accutane – Isotretinoin (13-cis retinoic acid) in its role as the most effective sebum-suppressive drug for the treatment of severe acne.
Accutane is a very effective drug for the treatment of Acne but it also comes with a pretty serious list of potential side effects primarily due to its mechanism of action
Accutane’s effect depends on sebocyte apoptosis ( Apoptosis is a form of programmed cell death ) which results from the isotretinoin-induced expression of the apoptotic protein tumor necrosis factor-related apoptosis-inducing ligand, insulin-like growth factor-binding protein-3 and neutrophil gelatinase-associated lipocalin.
This cell death may be the underlying and unifying mechanism of the adverse effects of isotretinoin on neural crest cells (teratogenicity), hippocampal neurones (depression), epidermal keratinocytes and mucosa cells (mucocutaneous side-effects), hair follicle cells (telogen effluvium), intestinal epithelial cells (inflammatory bowel disease), skeletal muscle cells (myalgia and release of creatine kinase), and hepatocytes (release of transaminases and very low-density lipoproteins).
Genetic variants of components of the apoptotic signaling cascade, such as RARA polymorphisms, might explain variations in the magnitude of isotretinoin induced apoptotic signaling and apparently identify subgroups of patients who experience either stronger adverse effects with isotretinoin therapy or resistance to treatment.
This effect can explain why some individuals experience near-permanent effects from acute administration.. education especially if we are going indulge in self-medication.
More to follow on this… I simply wanted to point out ” why” we don’t reach for Accutane as a ” first line treatment ”
Epigallocatechin-3-Gallate Green Tea Extract for Acne
Help with Acne ?
I get asked this a lot..
If you watch the Metformin Course you will see Metformin is a solution for Acne Treatment and a very effective one along with some Dietary Modifications
Still having some issues?
Next offering?
Epigallocatechin-3-Gallate – is an Over the Counter Solution that works..
Green Tea Extract.
Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea has attracted much interest in recent years because of its potent anticarcinogenic, anti-inflammatory,
and antimicrobial activities.
Accumulating evidence indicates that EGCG inhibits tumor progression and improves inflammatory diseases such as diabetes, allergies, and neurodegenerative disorders
In addition, a recent study showed that EGCG inhibits lipogenesis.
Just like everything else I try to use ” front line solutions” that are low risk and have multiple benefits to our tribe.
Victor Black
The first line of action of the Treatment of Acne?
In recent years there has been an increasing focus on the extent to which oxidative stress is involved in the pathophysiology of acne; studies have shown that patients with acne are under increased cutaneous and systemic oxidative stress.
Systemic Oxidative Stress ?
Does that sound like us ?
My recommendation for the first line of action of the Treatment of Acne?
Brassica Vegetables in your Diet ( Broccoli, Cauliflower, Brussel Sprouts, Kale, etc.)
Metformin
N-Acetylcysteine ( NAC )
Taurine
Green Tea Extract
All these things have multiple benefits for our tribe..
Save the Accutane for the “last line of action” not the first thing you do.
Cause the acne is likely your body talking to you… telling you ” I am under stress” that is the underlying reason you’re having acne issues… and masking that.. might not be a good idea..
Dosages
This IMO is going to depend on if you choose to deploy them all or a couple ?
Lets say you start them all
Brassica Vegetables in your Diet ( Broccoli, Cauliflower, Brussel Sprouts, Kale, etc.)
Metformin @ 500mg Day
N-Acetylcysteine ( NAC ) @ 1200 mg Day
Taurine @ 2000mg Day
Green Tea Extract @ 500mg Day
Yes you can titrate this dosage for effect.
Victor Black
