Careful attention to this one guys….

Understanding the significance of BUN and serum Creatinine screening tests of renal function.

Because BUN and serum Creatinine are modulated primarily by glomerular filtration with little or no renal regulation or adaptation in the course of declining renal function, these two health markers essentially reflect GFR.

IE the state of health or your kidneys..

This is the important part that few know.. here..

The relationship of BUN and serum Creatinine to GRF is not a straight line but rather a parabolic curve.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

What that means in simple language is their values remain within the normal range until more than 50{2658607c068490114260e14c260e6ae174f4b10b752c604f4a58b348bf83bb16} of renal function is lost.

Within that range, however, a doubling of the values (e.g., BUN rising from 8 to 16 mg/dl or sCr from 0.6 to 1.2 mg/dl) may mean a 50{2658607c068490114260e14c260e6ae174f4b10b752c604f4a58b348bf83bb16} fall in the GFR.

Therefore, in the early stages of renal disease, these tests could create a false sense of security.

once you cross the threshold that you start to see ” stress” these tests are generally adequate to follow a patient’s course.

At all stages of renal insufficiency, the sCr is a much more reliable indicator of renal function than the BUN because the BUN is far more likely to be affected by dietary and physiologic conditions not related to renal function

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Victor Black

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