Its past due that we stop spreading the Bro Myths about Testosterone and Prostate Cancer
No Elevated Testosterone is not the cause of Prostate Cancer
Clinical data indicate the saturation point for serum T is approximately 250 ng/dL
What this means is after you reach 250ng/dl.. the addition of ” more Androgens” has little to no cumulative effect on the Human Prostate..
The saturation model provided a radically different view, one that resolved an awkward paradox in which androgen deprivation clearly lowered prostate-specific antigen (PSA), yet raising T in hormonally intact men had little effect on PSA or prostate size. In one swoop, the Saturation Model assembled a messy assortment of clinical observations and experimental results into a coherent picture. Simply, the Saturation Model holds that prostate tissue is exquisitely sensitive to changes in serum androgens at low concentrations, and little to no sensitivity once a saturation point is reached.
c) once AR sites are fully occupied with T or 5α-DHT, a saturation state is achieved, beyond which increasing circulating T or 5α-DHT cannot elicit additional biological activity via this mechanism
At this point we conclude that the Saturation Model should no longer be considered a hypothesis, but rather an accurate framework describing the relationship of androgens and the prostate.icu-61-452
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