How to calculate the Human Equivalent Dosage from a Rat Model is not by simply multiply the Rats weight x the Humans weight
All Steriods and SARMs and similar drugs have traditionally been dosed in Rats at 1mg/kg
and 1mg/kg in a Rat is NOT 100mg in a 100kg Male – NO
To determine the Human Equivalent Dosage from a Rat Model at 1mg/kg
You multiply the Rat Dosage X 0.162 to arrive at the Human Equivalent Dosage in mg/kg
So 1mg/kg in a Rat is 0.162 mg/kg in a Human Model
So for a 100kg Male
1mg/kg in a Rat Model is 16.2mg in a 100kg Male
Not 200mg, no 16.2mg
Why on earth would we be testing what 200mg of a drug does in Humans based on an animal surrogate and then go test it in Humans at 4 mg ? Even that does not make any sense… just why ?
Toxicity Testing ? sure.. but for practical clinical use ?