Why I personally prefer ARB’s to ACE-Inhibitors for managing BP + .

2 reasons..

1, I am one of the individuals that suffer from the know side effect of the dry cough associated with ACE-Inhibitors, which makes the choice far easier for me.

2, There is some evidence that ARB’s has better ” cognitive function benefits” when compared to ACE-Inhibitors.

That they may be slightly more ” Neuro-Protective” against Dementia, maybe.

Observational studies suggest that ARBs may benefit cognition and be superior to other antihypertensives to reduce the risk of Alzheimer’s disease, but the evidence is not consistent.

Evidence to support this hypothesis.

1 meta-analysis for cognitive function
4 randomized controlled trials for cognitive function
1 meta-analysis of observational studies for risk of Alzheimer’s disease
4 observational studies for risk of Alzheimer’s disease/dementia
1 randomized controlled trial for risk of MCI and dementia
3 studies on Alzheimer’s disease pathology
1 randomized controlled trial in Alzheimer’s patients
2 observational studies of Alzheimer’s patients on risk of mortality
Numerous preclinical studies

So then which ARB and how much ?

There are 8 ARBs approved for use in the USA for the treatment of hypertension.

As the ARBs were developed during the 1990s, they were accompanied by longer half-lives and in some cases greater potency that translated into enhanced BP reductions and/or durations of action.

I use Irbesartan at 300mg a day, why ?

Long half live, high bio-availability and no food interaction

 

Moderates Blood Pressure
Actively lowers Hematocrit
Kidney Protective
LVH Heart Protective
Increases IGF-1
Protective against Dementia

All this from a single tablet.

I am NOT your Dr, you should consult your Dr about the use of Hypertension Medication even in a Preventative Role.

Victor Black

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